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COVID-19 Therapeutics Thresholds, Orders, and Replenishment by Jurisdiction

State and territorial health departments have the ability to order COVID-19 therapeutic products seven days a week through the Health Partner Ordering Portal (HPOP) in a process known as “threshold and replenishment.” In this process, the federal government replenishes the available supply, replacing products ordered by sites in the jurisdiction the previous week. This ensures that the total amount of product available to jurisdictions each week is consistent, and this amount is known as a jurisdiction’s "threshold quantity."

Paxlovid and Lagevrio (molnupiravir) threshold amounts are determined on a pro rata population basis and replenishment occurs weekly.

Requests for additional products can be made by state and territorial health department officials at any time if the current supply is not sufficient to meet demand. The federal government tracks the amount of COVID-19 therapeutic products ordered through the HPOP portal each week, monitoring product availability for each state or territory.

COVID-19 Therapeutics Summary: For All Open Distribution Channels1

December 17, 2021 – March 19, 2023

Therapeutic Courses Delivered Courses Administered2
Paxlovid3 12,776,335 8,640,385
Lagevrio 2,949,282 1,249,083
Total:
View Data by Jurisdiction
15,725,617 9,889,468

1States, territories, and federal entities, including HRSA
2Based on 92% of sites reporting as of March 19, 2023
3Includes Paxlovid and Renal Paxlovid
Data source: HHS-Tiberius

COVID-19 Therapeutics Summary: Previously Distributed Products

2020 – 2023

Therapeutics
(currently not in use)
Courses Delivered Courses Administered
Evusheld (300mg doses) 1,032,156 738,936
Bebtelovimab 739,889 624,633
REGEN-COV 2,878,138 2,078,587
Bamlanivimab/Etesevimab 642,125 610,753
Sotrovimab 706,692 302,209

COVID-19 Therapeutics Threshold Determinations

September 5, 2022 – March 26, 2023

Paxlovid
(Standard and Renal)
Lagevrio
(molnupiravir)
Evusheld Total
March 20 - March 26, 2023 612,165 48,604 - 660,769
March 13 - March 19, 2023 612,165 48,604 - 660,769
March 6 - March 12, 2023 612,165 48,604 - 660,769
February 27 - March 5, 2023 613,705 49,099 - 662,804
February 20 - February 26, 2023 612,165 48,604 - 660,769
February 13 - February 19, 2023 612,165 48,604 - 660,769
February 6 - February 12, 2023 612,115 48,296 - 660,411
January 30 - February 5, 2023 613,655 48,791 - 662,446
January 23 - January 29, 2023 612,115 48,296 0 660,411
January 16 - January 22, 2023 612,115 48,296 0 660,411
January 9 - January 15, 2023 612,060 48,240 0 660,300
January 2 - January 8, 2023 613,580 48,735 204,096 866,411
December 26, 2022 - January 1, 2023 612,060 48,240 0 660,300
December 19 - December 25, 2022 612,060 48,240 0 660,300
December 12 - December 18, 2022 612,060 48,240 0 660,300
December 5 - December 11, 2022 613,580 48,735 204,096 866,411
November 28 - December 4, 2022 612,060 48,240 0 660,300
November 21 - November 27, 2022 612,060 48,240 0 660,300
November 14 - November 20, 2022 612,060 48,240 0 660,300
November 7 - November 13, 2022 612,060 48,240 0 660,300
October 31 - November 6, 2022 613,580 48,735 204,096 866,411
October 24 - October 30, 2022 612,060 48,240 0 660,300
October 17 - October 23, 2022 612,060 48,240 0 660,300
October 10 - October 16, 2022 612,060 48,240 0 660,300
October 3 - October 9, 2022 613,580 48,735 204,096 866,411
September 26 - October 2, 2022 612,060 48,312 0 660,372
September 19 - September 25, 2022 612,060 91,920 0 703,980
September 12 - September 18, 2022 612,060 91,920 0 703,980
September 5 - September 11, 2022 612,060 91,920 0 703,980

Prior Distribution Efforts

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