Partnerships are the foundation of H-CORE. Its work requires close coordination across the federal government; private industry; and state, local and territorial governments. H-CORE leverages the expertise and experience found both inside and outside of government to accelerate solutions to public health threats, and then make those solutions available to the American people. For example, H-CORE collaborates with BARDA and the SNS within ASPR to accelerate solutions to public-health threats and then make those solutions available to the American people. Likewise, H-CORE works with ASPR’s Regional Emergency Coordinators (RECs) and Regional Medical Countermeasures Advisors (RMCAs) to conduct outreach and stakeholder engagement with state and territorial health departments. H-CORE uses commercial business practices to approach logistical challenges and integrates, prioritizes, and accelerates end-to-end solutions to combat these threats.